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Nexus Copy Number

Nexus Copy Number™ software offers simple yet powerful tools for copy number variation (CNV) analysis and visualization from aCGH, SNP array as well as next-gen sequencing (NGS) data.

The elegant user-interface and powerful statistical tools designed specifically for the end-user allow detection of structural variations (copy number, homozygous regions, sequence variations such as point mutations, InDels, insertions, etc.) and identification of affected pathways with just a few mouse clicks.

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from cytogenetics to large scale population studies…

Flexible

Support for any platform

  • Affymetrix
  • Agilent
  • Illumina
  • Roche NimbleGen
  • Next-Gen Sequencing
  • Other

Support for any organism
Simple addition of custom tracks
Choose/Create custom CNV database
Flexible licensing options

Powerful

Process and visualize thousands of samples.

  • Validated statistical aberration detection algorithms
  • Simple global collaboration support
  • Easy access to publically available data (e.g. GEO, TCGA, AGRE, ISCA)
  • Statistical tools for CNV/LOH and small sequence variation analysis
  • Statistical tools for survival analysis
  • Clustering
  • Enrichment analysis
  • Integration with miRNA/mRNA data


Nexus Expression

A new take on microarray gene expression analysis

Nexus Expression™ is a new addition to our Nexus line of products for microarray data analysis. Nexus Expression™ is a solution that is computationally very powerful but simple to use by scientists for answering common research questions. Our design objectives for this package have been the same as our very successful Nexus Copy Number™ product:

  • A platform independent solution.

    (support for all commercial platforms and custom arrays)

  • Efficient processing on a basic desktop computer.

    (hundreds of high density arrays can be processed in one project)

  • A user-friendly interface designed for end-user researchers not informaticians.

    (no programming knowledge needed)

Nexus Expression™ provides an intuitive and streamlined approach to convert raw signal values into meaningful information by integrating sample phenotypes (e.g., disease stage, survival, age, sex, etc.) with gene annotations (e.g. GO terms).

Users can effortlessly navigate large datasets and generate results with a few mouse clicks. For example, in a cancer study, differentially regulated genes in the HER2 positive sub-population as compared to HER2 negative can be identified in one click and the affected biological processes can be identified with another click. Using a sophisticated ANOVA engine under the hood, the user can easily compare between subgroups, cluster samples and genes, view annotations and perform gene enrichment all with single clicks.

Nexus Expression™ is platform agnostic so data from multiple commercial (e.g. Affymetrix, Agilent, Exiqon, Illumina, Roche NimbleGen) and custom platforms can be loaded, processed, and viewed with ease.

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